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PROJECT TOPIC- SYNTHESIS, CHARACTERIZATION AND PRELIMINARY ANTIMICROBIAL ACTIVITIES OF SOME AZO LIGANDS DERIVED FROM AMINOANTIPYRINE AND THEIR Co(II), Fe(III), AND Os(VIII) COMPLEXES

PROJECT TOPIC- SYNTHESIS, CHARACTERIZATION AND PRELIMINARY ANTIMICROBIAL ACTIVITIES OF SOME AZO LIGANDS DERIVED FROM AMINOANTIPYRINE AND THEIR Co(II), Fe(III), AND Os(VIII) COMPLEXES

 

 

ABSTRACT

Synthesis, electronic, infrared ,NMR, and preliminary antimicrobial activities were carried out on three new azo-ligands derived from 4-aminoantipyrine namely: 1,2-dihydro-1,5-dimethyl-2-phenyl-4-[(E)-(2,3,4-trihydroxyphenyl)-3H-pyrazol-3-one (H3L), 7-[(E)-(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)diazenyl]-1H-indole-2,3-dione (L) and 1,2-dihydro-4-(E)-[3-hydroxy-4{(E)-phenyldiazenyl}-1-naphthalenyl]-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one(HL) and their Co(II), Fe(III) and Os(VIII) complexes. Their coordination chemistries with Co(II), Fe(III), and Os(VIII) respectively have been investigated. The stoichiometry and molar conductance studies of the complexes were equally determined. Stoichiometric studies indicated the complexes formed by Co(II) and Os(VIII) with H3L to have 2:1 ligand to metal mole ratio. The [Fe(H2L)2]+ complex could not be determined by this method. For L ligand, it had 1:1 ligand to metal mole ratio stoichiometry with Co(II) and Fe(III) ions. The Os(VIII) complex of L ligand was not isolated. For HL ligand, both [Co(HL)2(OH2)2] and [Fe2O(HL)2Cl2] have 2:1 ligand to metal mole ratio . The [Os(HL)2(O)2Cl2] could not be determined by this method. Based on the spectroscopic studies, H3L was observed to be bidentate and ligated via its azo nitrogens and carbonyl group to Os(VIII) . In coordinating to Co(II) and Fe(III) the ligand displayed terdenticity. The azo nitrogen, carbonyl oxygen and one oxygen of the trihydroxylbenzene were involved . L was observed to be terdentate through the participation of isatin nitrogen, azo nitrogen and carbonyl group of antipyrine to Co(II) ion. In bonding with Fe(III), it was observed to be bidentate through the participation of its azo nitrogens and its carbonyl group from antipyrine . HL was observed to be bidentate through the participation of azo nitrogen and carbonyl group of antipyrine in bonding with both Co(II) and Fe(III) and Os(VIII). The sensitivity of clinical isolates of Pseudomonas aeruginosa, Staphylococcus eureus, Candida albican and Escherica coli towards the ligands and complexes were determined via the agar-well diffusion method. Ampicilin was used as control.

CHAPTER ONE
INTRODUCTION

1.1 PYRAZOLONE AND PYRAZOLIDINE DIONE DERIVATIVES:

Pyrazolone is a five – membered lactam ring compound containing two nitrogen atoms and ketone in the same molecule. Lactam structure is an active nucleus in pharmacological activity. Pyrazolone is an active moiety as a pharmaceutical ingredient, especially in the class of nonsteroidal anti-inflammatory agents used in the treatment of arthritis and other musculoskeletal and joint disorders1
The term pyrazolone sometimes refers to nonsteroidal anti-inflammatory agents. Pyrazolone class nonsteroidal anit-inflammatory drug (NSAID) includes phenylbutazone, oxyphenbutazone, dipyrone, and ramifenazone. Antipyrine (also called phenazone) is a pyrazolone class analgesic agent in solutions in combination with other analgesic such as benzocaine, and phenylphrine2 .
Pyrazolone derivatives are also used in preparing dyes and pigments3 .

PROJECT TOPIC- SYNTHESIS, CHARACTERIZATION AND PRELIMINARY ANTIMICROBIAL ACTIVITIES OF SOME AZO LIGANDS DERIVED FROM AMINOANTIPYRINE AND THEIR Co(II), Fe(III), AND Os(VIII) COMPLEXES

 

2, 3-Dimethyl -1-phenyl -5-pyrazolone (antipyrine) has been discovered as antipyretics of the quinoline type4. This discovery initiated the beginning of the German drug industry that dominated the field for approximately 40 years.
Phenylbutazone, was originally developed as a solubilizer for the insoluble aminopyrine. It is now used for the relief of many forms of arthritis in which capacity it has more than an analgesic action in that it also reduces swelling and spasm by an anti –inflammatory action.

PROJECT TOPIC- SYNTHESIS, CHARACTERIZATION AND PRELIMINARY ANTIMICROBIAL ACTIVITIES OF SOME AZO LIGANDS DERIVED FROM AMINOANTIPYRINE AND THEIR Co(II), Fe(III), AND Os(VIII) COMPLEXES

 

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